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何炜
2015-09-02 09:14     (点击: )

何炜第四军医大学药学系化学教研室主任、教授、博士生导师、陕西省化学会理事、中国细胞生物学学会细胞工程与转基因生物分会委员,总后勤部优秀教师,学校“双十佳”精品教员。1990.09-1994.07在西北大学有机合成专业获学士学位,1996.09-1999.07西北大学有机化学专业获硕士学位,2003.09-2006.06第四军医大学药物化学专业获博士学位。2004.06-2004.12赴澳大利亚悉尼大学学习交流。2007.02-2008.10赴香港大学化学系杨丹教授课题组从事博士后研究。

目前作为课题负责人承担“十二五”国家重大新药创制课题1项、国家自然科学基金课题3项、陕西省科技统筹计划重点项目1项、陕西省自然科学基金1项,分题负责国家重大新药创制项目2项。近年来发表科研论文60余篇(其中SCI收录期刊40余篇),获国家发明专利授权7项。先后多次获学校嘉奖,2005年获学校“学术新人”基金奖励,2007年获陕西省科学技术奖一等奖,2009年入选第四军医大学精英人才库第一层次,2010年获“药学精品年会”优秀论文金奖,同年获第四军医大学“精品教员”称号,2011年荣立个人三等功,指导的研究生2012年获全军优秀硕士学位论文奖。2014年获得军队院校育才奖银奖,同年被评为学校“双十佳”精品教员。获军队优秀专业技术人才三类岗位津贴。

先后主讲有机化学、无机化学、医用化学、药用高分子材料、药学研究新进展等课程,发表教学论文10余篇,主编《有机化学》、《有机化学学习指导》(科学出版社,“十二五”普通高等教育本科国家级规划教材;主编《医用化学》(化学工业出版社,高等学校“十二五”规划教材);副主编《国家医学电子书包—有机化学》(人民军医出版社);副主编《色谱分析》(第四军医大学出版社);参编人民卫生出版社国家规划教材2部,参编学术专著《不对称催化新概念与新方法》等。主持军队和各级教学课题3项,发表教学论文10余篇,2013年牵头获得陕西省教学成果二等奖。

主要研究方向:(1)手性催化剂、不对称催化反应方法学的研究,并将方法学研究成果用于生物活性分子的全合成研究;(2)新药设计合成及工艺研究;(3)功能有机分子的合成及性能研究;(4)天然产物中活性单体化合物的分离、纯化、结构改造、质量标准及生物活性研究。

代表性论文

1.Wei He, Kai-Tai Yip, Nian-Yong Zhu,Dan Yang. Novel Chiral Catalyst System for Enantio-selective Oxidative CascadeCyclization Using Pd(II)/tBu-quinolineoxazoline.Org. Lett.2009,11, 5626-5628.

2.Hua Li, XuZhang,Wei He*, Shengyong Zhang. Modular Bifunctional ChiralThioureas as Versatile Organocatalysts for Highly Enantioselective Aza-HenryReaction and Michael Addition.Adv Synth & Cat.2012, 354,2264-2274.

3.Yu Wei,WeiHe*, Yu-long Liu, Peng Liu, Shengyong Zhang. HighlyEnantioselective Nitro-Mannich Reaction Catalyzed by Cinchona Alkaloids andN-BenzotriazoleDerived Ammonium Sa-lts.Org. Lett.2012, 14, 704–707.

4.MinghuaLi, Nan Ji, Ting Lan,Wei He*, Rui Liu. Construction ofchiral quaternary carbon center via catalytic asymmetric aza-Henry reactionwith α-substituted nitroacetates.RSC Advances, 2014, 4, 20346-20350.

5.YulongLiu, Xie Wang, Xiaoyun Wang,Wei He*. Highly enantioselectiveMichael addition of diethyl malonate to chalcones catalyzed by cinchonaalkaloids-derivatived bifunctional tertiaryamine-thioureas bearing multiplehydrogen-bonding donors.Org. Biomol. Chem., 2014, 12, 3163-3166. (COVERIMAGE)

6.Yu Wei,Lin Yao,Wei He*, Shengyong Zhang. Novel Schiff base ligandsderived from Cinchona alkaloids for Cu(II)-catalyzed asymmetric Henry reaction.Tetrahedron, 2011,67, 8552 -8558

7.Lin Yao,Yu Wei,Wei He*, Shengyong Zhang. Promotion of Henryreactions using Cu(OTf)2and a sterically hindered Schiffbase:access to enantioenrichedβ-hydroxynitroalkanes.Tetrahedron,2012, 68, 9119-9124.

8.Nan Ji,Jiani Yuan, Shanshan Xue, Junna Zhang,Wei He*. Novel chiralthiourea organocatalysts for the catalytic asymmetric OxaziridinationBifunctional Schiff base/Ti(IV) catalysts for enantioselective cyanoformylationof aldehydes with ethyl cyanoformate.Tetrahedron, 2016, 72,512-517.

9.Xin Shi,WeiHe*. Highly efficient and enantioselective Michael addition ofacetylacetone to nitroolefins catalyzed by chiral bifunctional organocatalystbearing multiple hydrogen-bonding donors.Tetrahedron Lett.2011, 52,3204–3207.

10.Meiyu Liu,Xie Wang, Xiaoliang Sun,Wei He*. Highly selectiveN-allylation of anilines under microwave irradiation.Tetrahedron Lett.,2014, 55, 2711-2714.

11.Yu Wei,Wei He*.The Application of Chiral Schiff Base in Asymmetric Catalysis.Minireviewin Organic Chemistry. 2011, 8, 66-90.

12.Nan Ji,Lin Yao,Wei He*. Bifunctional Schiff base/Ti(IV) catalystsfor enantioselectivecyanoformylation of aldehydes with ethyl cyanoformate.Appl.Organometal. Chem.2013, 27, 209–213.

13.Wei He, Quanjun Wang, Qiiaofeng Wangand Shengyong Zhang. Synthesis of Novel Chiral Phase-Transfer Catalysts andtheir Application to Asymmetric Synthesis of Amino-acids Derivatives.Synlett, 2009, 8, 1311-131.

14.Wei He, Bangle Zhang, Ru Jiang, PengLiu, Shengyong Zhang. Novel Recoverable Catalysts for Asymmetric TransferHydrogenation.Tetrahedron Letters, 2006,47: 5231-5235.

15.Wei He, Peng Liu, Bangle Zhang,Shengyong Zhang. Efficient iridium and rhodium-catalyzeasymmetric transferhydrogenation using 9-amino(9-deoxy) cinchona alkaloids as chiral ligands.Applied Organometallic Chemistry, 2006, 20: 328-334.

16.Wei He*.Oxone.Synlett. 2006,20, 3548-3549.

17.Wei He, Bangle Zhang, Zhongjie Li,Shengyong Zhang. PTC promoted Japp-Klingmann Reaction for the synthesis ofIndole Derivatives.Synthetic Communications,2005, 35(10):1359-1368.

18.Wei He, Bangle Zhang,ShengyongZhang. A Facile Total Synthesis of Xanthotoxol.Synthetic Communications,2007,37:361-367.

19.Wei He,Peng Liu,Shengyong Zhang.Synthesis of the Chiral Diamine Ligands Derived from Cinchona Alkaloids andTheir Catalytic Performance in Asymmetric Transfer Hydrogenation.Chin.Journal of Catalysis, 2006,27(6): 515-519.

20.Wei He, Bangle Zhang,ShengyongZhang. A novel Class of Chiral Phase Transfer Catalysts and Their CatalyticPerformance.Chin.Journal of Org. Chem.,2006, 26(7):1008-1011.

21.Wei He, Mike King. Considerationsabout studentcentered Strategies of Organic chemistry.Tertiary Science andMathematics for the 21st Century, 2004, 11: 14-18.

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