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周四元
2015-09-02 09:16     (点击: )

周四元,第四军医大学药学系药剂学教研室主任、教授,药剂学和药理学专业博士研究生导师。获第四军医大学药理学专业博士学位,曾留学美国从事博士后研究。国家药品价格评审专家,陕西省药理学会常务理事、副秘书长,陕西省生理学会理事,陕西省药学会临床药理学专业委员会委员。

作为课题负责人承担国家863课题2项、陕西省科技创新统筹计划课题1项,陕西省科技攻关等课题1项,参与重大新药创制、国家自然科学基金等课题10余项。获陕西省科学技术一等奖1项,发表科研论文100余篇,其中SCI收录论文30余篇,获授权国家发明专利5项。主讲药剂学、生物药剂学与药物动力学等课程,发表教学研究论文10余篇,获军队院校育才银奖,第四军医大学精品课教员。曾荣立个人三等功1次。

长期以来主要从事新型递药系统以及药物代谢动力学研究。

(1)靶向递药系统研究:功能药物载体材料设计、合成及应用研究,靶向纳米递药系统的设计、制备、表征及活性研究。

(2)缓控释递药系统研究:缓释微球、脂质体、纳米乳、亚微乳等剂型的设计、制备及应用研究。

(3)药物代谢动力学研究:药物转运、代谢机制及肠道吸收预测研究,纳米制剂细胞及动物体内药物动力学研究,新制剂生物等效性研究。

联系方式zhousy@fmmu.edu.cn,029-84776783

5年发表的主要论文

[1]Ye WL, Zhao YP, Li HQ, Na R, Li F, Mei QB, Zhao MG, Zhou SY*. Doxorubicin-poly(ethylene glycol)-alendronate self-assembled micelles for targeted therapy ofbone metastatic cancer. Sci Rep. 2015 Sep 30;5:14614.

[2]Cheng Y, Liu M, Hu H, Liu D, Zhou S. Development, Optimization, andCharacterization of PEGylated Nanoemulsion of Prostaglandin E1 for LongCirculation. AAPS PharmSciTech. 2015 Jul 21. [Epub ahead of print]

[3]YeWL, Zhao YP, Na R, Li F, Mei QB, Zhao MG, Zhou SY. Actively Targeted Deliveryof Doxorubicin to Bone Metastases by a pH-Sensitive Conjugation. J Pharm Sci.J Pharm Sci. 2015;104(7):2293-303.

[4]Du JB, Song YF, Ye WL, Cheng Y, Cui H, Liu DZ, Liu M,Zhang BL,Zhou SY*. PEG-detachable lipid-polymer hybrid nanoparticle toactive deliver chemotherapy drug to cancer cells. Anticancer Drugs.2014;25(7):751-66.

[5]Ye WL, Du JB, Zhang BL, Na R, Song YF, Mei QB, Zhao MG,Zhou SY*. Cellular Uptake and Antitumor Activity of DOX-hyd-PEG-FANanoparticles. PLoS One. 2014;9(5):e97358.

[6]Liang CH, Ye WL, Zhu CL, Na R, Cheng Y, Cui H, Liu DZ,Yang ZF,Zhou SY*. Synthesis of Doxorubicin α-Linolenic Acid Conjugateand Evaluation of Its Antitumor Activity. Mol Pharm. 2014;11(5):1378-90.

[7]Wang HB, Jia YJ, Gao P, Cheng Y, Cheng M,Zhou SY*,Sun XL*. Synthesis, radioprotective activity and pharmacokinetics characteristicof a new stable nitronyl nitroxyl radical-NIT2011. Biochimie. 2013;95(8):1574-81.

[8]Li Q,ZhouS(co-first author), Jing J, Yang T, Duan S, Wang Z, Mei Q,Liu L. Oligosaccharide from apple induces apoptosis and cell cycle arrest inHT29 human colon cancer cells.Int J Biol Macromol.2013;57:245-54.

[9]Zhou SY, Yang TH, Jacobson KA, Liang BT*. The therapeutic effect of 2-cyclohexylthio-AMP inheart failure. J Cardiovasc Pharm.2013;61(6):553-9.

[10]Su D, Cheng Y, Liu M, Cui H, Zhang B,Zhou S*,Yang T*,Mei Q*. Comparision of piceid and resveratrol in antioxidation andantiproliferation activities in vitro. PLoS One. 2013; 8(1):e54505.

[11]Ye WL, Teng ZH, Liu DZ, Cui H , Liu M,Cheng Y, Yang TH, Mei QB,Zhou SY*.Synthesis of a new pH-sensitivefolate-doxorubicin conjugate and its antitumor activity in vitro.J Pharm Sci. 2013; 102(2):530-540.

[12]Yang TH, Jia M, Yue ZG, Cheng Y, Zhang XX, Huang JJ,Zhou SY*,Mei QB*.Synergistic antivirus effect of combined administration of combivirwith angelica polysaccharide sulphate. Int J Biol Macromol.2013; 53(1):122-126.

[13]Teng Z, Yuan C,Zhang F,Huan M,Cao W,Li K,Yang J, Cao D,Zhou S*, Mei Q*. Intestinal absorption and first-pass metabolismof polyphenol compounds in rat and their transport dynamics in Caco-2 cells.PLoS One.2012; 7(1):e29647.

[14]Wang XJ,Cui H, Wang R, Huan ML, Zhang BL, Zhang WD, Teng ZH, Gan HQ,Zhou SY*, GuY*. Metabolism and Pharmacokinetic Study of Ardipusilloside I in Rat. PlantMedica. 2012; 78(6):565-74.

[15]Liu RW,Teng ZH, Yuan CJ, Huan ML, Liu XY, Zhou SY*. Liquid chromatography/positive-ionelectrospray tandem mass spectrometry assay for nisoldipine in human plasma andits application to a pharmacokinetic study. Journal of Liquid Chromatography& Related Technologies. 2011; 34(16):1800-1810.

[16]ZhangWD, Wang XJ,Zhou SY*, Gu Y, Wang R, Zhang TL, Gan HQ. Determinationof free and glucuronidated kaempferol in rat plasma by LC-MS/MS: application topharmacokinetic study.J Chromatogr B Analyt Technol Biomed Life Sci. 2010; 878(23):2137-40.

[17]ZhouSY, Mamdani M, Qanud K,Shen JB, Pappano AJ, Kumar ST, Jacobson KA, Hintze T, Recchia F, Liang B.Treatment of heart failure by a methanocarba derivative of adenosinemonophosphate: implication for a role of cardiac P2X purinergic receptors.J Pharmacol Exp Ther.2010; 333(3):920-8.

[18]Kumar TS,Zhou SY,Joshi BV,Balasubramanian R,Yang T,Liang BT,Jacobson KA.Structure-activity relationship of (N)-methanocarba phosphonate analogues of5'-AMP as cardioprotective agents acting through a cardiac P2X receptor.J Med Chem.2010; 53(6):2562-76.

[19]ZhangBL, He W, Shi X, Huan ML, Huang QJ,Zhou SY*. Synthesis and biologicalactivity of the calcium modulator (R) and (S)-3-methyl 5-pentyl2,6-dimethyl-4-(3-nitrophenyl)-1,4- dihydropyridine-3,5-dicarboxylate. Bioorg Med Chem Lett.2010; 20(3):805-8.

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