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王四旺
2015-09-02 09:21     (点击: )

王四旺,男,1957年12月出生于湖北武汉,1980年毕业于第四军医大学。现任第四军医大学药学系天然药物学教研室教授,药学系新药研究中心主任,博士研究生导师。主要学术任职:解放军中医药学会理事、全军中药专业委员会副主任委员、陕西省生理科学会副理事长兼秘书长、陕西省药理学会中药药理专业委员会副主任委员,兼任国家科学技术奖励评审专家、国家教育部药学类教学指导委员会委员、国家教育部中药学教学指导委员会委员,国家自然科学基金委员会评审专家,国家、军队和陕西省新药评审专家。

从事中药学教学和天然药物科研工作30余年。获中国专利优秀奖(2014-1)、陕西省科学技术一等奖2项(2008-1/2012-1)、陕西省教学成果一等奖1项(2013-2)、陕西省专利一等奖1项(2013-1)、军队科技进步二等奖2项(1990-4/1997-1);先后荣立个人三等功2次(1999/2002);2006年获军队院校育才银奖,2007年获中国药学发展奖,2010年被中共陕西省委和陕西省人民政府授予三秦学者,2011年被聘为陕西省科技厅创新药物研究首席专家、获军队优秀专业技术人才二类岗位津贴,2012年享受国务院政府特殊津贴。

先后负责国家重大新药创制重大专项、国家自然科学基金和陕西省创新药物研究等课题32项,目前在研课题5项(总经费1720万元);主持研制国家新药18项,已获国家新药证书4项和临床批件6项(均已技术转让);主持成功研制53种军队医疗机构非标准/标准制剂研究,均获制剂批准文号并应用于临床;第1或通讯作者发表科研论文418篇,其中国外SCI收录88篇(最高IF=7.348,总IF=241.96);获授权中国专利46项(25项-1);主编/副主编专著或教材15部;培养硕士、博士研究生和博士后78名。

研究方向

1、中药组方理论研究:提出“中药分子、分子中药和方证组方”等新的学术观点,发表一系列学术论文,主编出版《中药药效学研究与评价》和《分子中药研究与方法学》等学术专著。采用现代谱效关键技术,建立中药科学质控标准,重点针对临床应用广泛、疗效确实、副反应小的中药标准制剂实施物效成分分析与研究,旨在阐明中药制剂功效成分的同时,诠释其中药的组方原理。

2、新药的发现与创制:(1)分子中药研究。采用现代医学和分子生物学技术,探讨和发现中药在体内发挥作用的有效分子,经成分表征再进行方证组方和“药学、药理学和临床”系列优效性评价,创研成分清楚、靶点明确的分子中药。(2)创新天然药物研究。针对心脑血管、肿瘤等重大疾病,从药用植物中获得天然产物并按照规范的药学、药效学和安全性评价等创制高效低毒1类新药。

3、上市药品的再评价:主要针对已上市中成药实施物效成分、体内药代动力学、新功效发现和多药作用关系及其安全性研究;为提高上市药品的质量和科学内涵及合理、安全的临床应用提供科学依据。

近年发表的代表论文

1.Cao W,Xie YH,Li XQ*,Zhang XK,Chen YT,Kang R,Chen X,Miao S,WangSW*. Burn-induced apoptosis of cardiomyocytes is survivin dependent andregulated by PI3K/Akt, p38 MAPK and ERK pathways[J].Basic Research inCardiology. 2011,106(6):1207-1220

2.Shan Miao, Xiaopeng Shi, Hai Zhang,SiwangWang*, Jiyuan Sun, Wei Hua, Qing Miao, Yong Zhao and Caiqin Zhang.Proliferation-Attenuating and Apoptosis-Inducing Effects of Tryptanthrin onHuman Chronic Myeloid Leukemia K562 Cell Line in Vitro[J].Int. J. Mol. Sci.2011,12:3831-3845

3.Qing Miao,Siwang Wang*, Shan Miao, Jianbo Wang*, Yanhua Xie and QianYang.Cardioprotective effect of polydatinagainst ischemia/reperfusion injury: Roles of protein kinase C and mito KATPactivation[J].Phytomedicine.2011,19(1):8-12

4.Hua Li,SwangWang*, Bang-Le Zhang*, YanHua Xie, Qian Yang, Wei Cao, Jian-BoWang. Simultaneousquantitative determination of 9 active components in traditional Chinesemedicinal preparation ShuangDan oral liquid by RP-HPLC coupled with photodiodearray detection[J].J Pharm Biomed Anal.2011,56:820-824

5.Linlin Bi, Xiangrong Tian, FangDou, Liangjian Hong, Haifeng Tang*,Siwang Wang*,New antioxidant and antiglycation activetriterpenoid saponins from the root bark of Aralia taibaiensis[J].Fitoterapia.2012,83:234-240

6.Hua Li,Siwang Wang*,BangleZhang*,Yanhua Xie,Jianbo Wang,Qian Yang,Wei Cao,Jing Hu,Linrui Duan. Influenceof co-administered danshensu on pharmacokinetic fate and tissue distribution ofpaeonol in rat[J].Planta Med.2012,78(2):135-140

7.Qing Miao,Jingge Li,ShanMiao(co-author),Nan Hu,Jin Zhang,Song Zhang,Yanhua Xie,Jianbo Wang*,SiwangWang*. TheBone-Protective Effect of Genistein in the Animal Model of BilateralOvariectomy: Roles of Phytoestrogens and PTH/PTHR1 Against Post-MenopausalOsteoporosis[J].Int. J. Mol. Sci.2012,13:56-70

8.Jingqun Huang, Miaozhang Zhu, Ye Tao,SiwangWang*,Jianzong Chen,Wenjuan Sun and Shuye Li. Therapeutic properties of quercetin onmonosodium urate crystal-induced inflammation in rat[J].Journal of Pharmacy and Pharmacology. 2012,64:1119-1127

9.Qing Miao, Xiao-Peng Shi,Ming-Xiang Ye, Jin Zhang, Shan Miao,Siwang Wang*, Bo Li, Xiu-Xiu Jiang, Song Zhang, NanHu, Juan Li and Jian Zhang*. PolydatinAttenuates Hypoxic Pulmonary Hypertension and Reverses Remodeling throughProtein Kinase C Mechanisms[J].Int. J. Mol. Sci.2012,13:7776-7787

10.Ya Zhang, Wei Cao, Yan-Hua Xie,Qian Yang, Xiao-Qiang Li, Xin-Xin Liu,Siwang Wang*.The comparison ofα-bromo-4-chlorocinnamaldehyde and cinnamaldehyde on coxsackie virus B3-inducedmyocarditis and their mechanisms[J].International Immunopharmacology.2012,14(1):107-113

11.Jin Zhang, Qing Miao, YangYang, Bo Xiao, Bei Liu, Jiao Cao, Xiao-Yan Hao,Siwang Wang*and Shu-Zhong Guo*.Effectof combined OX40Ig and CTLA4Ig gene local transfer on allograft rejection andthe underlying mechanisms[J].J Surg Res.2012,178(2):949-958

12.Hua Li, Yanhua Xie, Qian Yang,SiwangWang*, Bangle Zhang*, Jianbo Wang, Wei Cao, Linlin Bi, JiyuanSun, Shan Miao, Jing Hu, Xuanxuan Zhou, Pengcheng Qiu. Cardioprotective effectof paeonol and danshensu combination on isoproterenol-induced myocardial injuryin rats[J].Plos One. 2012,7(11):e48872. doi: 10.1371

13.Jing Hu, Yaling Li, Zilin Li, Hua Li,Xuanxuan Zhou, Pengcheng Qiu, Qian Yang andSiwang Wang*.Chronic supplementation of paeonol combined with danshensu for the improvementof vascular reactivity in the cerebral basilar artery of diabetic rats [J].IntJ Mol Sci, 2012,13(11): 14565-14578

14.Zi-lin Li, Jing Hu, Zhuo Li, Feng Xue, LiZhang, Hua Li, Xiaodong Zhou, Ding-hua Yi, Jin-cheng Liu*,Siwang Wang*.The effect of hyperoside on the functional recovery of theischaemic/reperfused isolated rat heart: potential involvement of theextracellular-signal regulated kinase1/2 signaling pathway[J].Free Radical Biology & Medicine.2013,57C:132-140

15.Qing Miao, Lin-Lin Bi, Xin Li, Shan Miao,Jin Zhang, Song Zhang, Qian Yang, Yan-Hua Xie, Jian Zhang* andSiwangWang*. Anticancer Effects of Bufalin on Human Hepatocellular CarcinomaHepG2 Cells: Roles of Apoptosis and Autophagy[J].Int. J. Mol. Sci.2013,14:1370-1382

16.Yuetao Chen, Yu Cao, Yanhua Xie, XiaokaiZhang, Qian Yang, Xiaoqian Li, Jiyuan Sun, Pengcheng Qiu, Wei Cao*,Siwang Wang*. Traditional ChineseMedicine for the treatment of primary dysmenorrhea: How do Yuanhu painkillerseffectively treat dysmenorrhea?[J]Phytomedicine.2013,20: 1095-1104

17.Fan Song, Hua Li, Jiyuan Sun*,SiwangWang*. Protective Effects of Cinnamic Acid and Cinnamic Aldehyde onIsoproterenol-Induced Acute Myocardial Ischemia in Rats[J].Journalof Ethnopharmacology.2013, 150:125-130

18.Hang Zhao, Yanhua Xie, Qian Yang, Yu Cao,Honghai Tu, Wei Cao*,Siwang Wang*.Pharmacokinetic study of cinnamaldehyde in rats by GC-MS after oral andintravenous administration [J].J Pharm Biom Ana. 2014, 89:150-157

19.Chen Lu, Jin Zhang, Xiaopeng Shi, Shan Miao, Linlin Bi, Song Zhang,Qian Yang, Xuanxuan Zhou, Meng Zhang, Yanhua Xie, Qing Miao,Siwang Wang*.Neuroprotectiveeffects of tetramethylpyrazine through anti-apoptotic and antioxidant roles inParkinson's disease induced by MPTP in rats[J].INTJ BIOL SCI.2014; 10(4): 350-357

20.Ying Li,Hang Zhao,Lin-Rui Duan,Hua Li,Qian Yang,Hong-Hai Tu,Wei Cao*,Si-Wang Wang*.Preparation,characterization and evaluation of bufalin liposomes coated with citruspectin[J].Colloids and Surfaces APhysicochemical and Engineering Aspects. 2014, 444:54-62

21.Ying li†,Jiani Yuan†,Qian Yang,Wei cao*,Xuanxuan Zhou,Yanhua Xie,honghaiTu,Ya Zhang,Siwang Wang*.Immunoliposome co-delivery of bufalin andanti-cD40 antibody adjuvant induces synergetic therapeutic effiacy againstmelanoma[J].International Journal of Nanomedicine.2014;9: 5683-5700

22.Xuanxuan Zhou1, Qian Yang1, Yanhua Xie1,Jiyuan Sun, Jing Hu,Pengcheng Qiu, Wei Cao*,Siwang Wang**.Tetrahydroxystilbene glucoside extends mouse life span via upregulating neural klotho anddownregulating neural insulin or insulin-lik e growth factor 1[J].Neurobiologyof Aging.36(2015)1462-1470

23.Fan Song, Jing Zhao, Fei Hua, Lun Nian,Xuan-Xuan Zhou, Qian Yang, Yan-Hua Xie, Hai-Feng Tang,Ji-Yuan Sun*,Si-WangWang**. Proliferation of rat cardiac stem cells is induced by 2, 3,5,4′- tetrahydroxystilbene-2-O-β-D-glucoside in vitro[J].Life Sciences.132(2015) 68-76

近年出版的代表专著

1.王四旺,施新猷,黄传贵,谢艳华主编.《中药药效学研究与评价》:陕西:陕西科学技术出版社出版, 2006年第一版;ISBN:7-5369-3987-6

2.王四旺,谢艳华,曹蔚主编.《分子中药研究与方法学》,北京:军事医学科学出版社,2012年7月第一版;ISBN:978-7-80245-975-5

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