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招明高
2015-09-02 09:25     (点击: )

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招明高,1968年8月生。第四军医大学药学院药理学教研室主任、教授、博士生导师。教育部长江学者特聘教授,国家杰出青年基金获得者,总后勤部“科技新星”。1993年毕业于第四军医大学六年制医疗系,1996年和2001年分别获第四军医大学药理学专业硕士学位和博士学位。2002-2006年分别在德国Goettingen大学和加拿大多伦多大学从事博士后研究。现为中国药理学会理事、中国神经科学会理事、全军药学专业委员会委员、陕西省药理学会副理事长,Mol Pain编委。主要从事中枢可塑性与中枢疾病药物新靶点发现的研究。中枢神经系统突触可塑性、学习记忆和情感障碍的分子机制研究。主要学术贡献有:(1)在脆性X综合症中枢可塑性障碍病理机制研究中,发现脆性X综合症动物额叶皮层突触可塑性降低;多巴胺D1受体和雌激素易化LTP作用消失;胶质细胞分泌的神经营养因子-3(NT-3)异常增加并导致神经元突触发育障碍;雌激素信号系统异常引起可塑性障碍。从全新的角度诠释脆性X综合症发病机制,为发掘新的药物靶点奠定理论基础。论文发表在Neuron, Ann Neurol, Brain, PLoS Genet等杂志,得到国际同行的高度关注与认可,并在Nature发表专文评述我们的创新性发现。(2)在可塑性分子机制研究中,发现NMDA受体NR2B亚基参与扣带回皮层LTP的诱导与恐惧记忆形成;抑制突触外NMDA受体NR2B亚基磷酸化介导了雌激素快速神经保护作用;以调节NR2B功能的新策略为开发神经保护药物提供了新的思路。系列研究发表在Neuron,J Neurosci, Sci Signal等杂志。结合基础研究发现,将新药靶点发现与创新药物研究相结合,三项候选药物获得国家“重大新药创制”立项进入临床前研究,有望在新型抗焦虑症、老年痴呆症和慢性痛药物研究方面取得进展。十余年来,共获得国家杰出青年基金、国家自然科学基金面上项目、重大新药创制专项、重大国际合作、陕西省创新制剂工程中心等课题10余。在SCI收录杂志发表论文110篇,被国际同行引用2000余次;获得发明专利5项。

代表性论文

1.1Zhang K, Li YJ, Guo Y, Zheng KY, Yang Q, Yang L, Wang XS, Song Q, Chen T, Zhuo M, Zhao MG. Elevated progranulin contributes to synaptic and learning deficit due to loss of Fragile X mental retardation protein. Brain. 2017, 140 (12), 3215–3232

2.Zhang K, Li YJ, Feng D, Zhang P, Wang YT, Li X, Liu SB, Wu YM, Zhao MG. Imbalance between TNFα and progranulin contributes to memory impairment and anxiety in sleep-deprived mice. Sci Rep. 2017 Mar 16;7:43594

3.Yang Q, Yang L, Zhang K, Guo YY, Liu SB, Wu YM, Li XQ, Song Q, Zhuo M, Zhao MG. Increased coupling of caveolin-1 and ERα contributes to the Fragile X syndrome. Ann Neurol. 2015 Apr;77(4):618-36

4.Liu SB, Tian Z, Guo YY, Zhang N, Feng B, Zhao MG. Activation of GPR30 attenuates chronic pain-related anxiety in ovariectomized mice. Psychoneuroendocrinology. 2015;53:94-107

5.Wang M, Li YJ, Ding Y, Zhang HN, Sun T, Zhang K, Yang L, Guo YY, Liu SB, Zhao MG*, Wu YM*. Silibinin Prevents Autophagic Cell Death upon Oxidative Stress in Cortical Neurons and Cerebral Ischemia-Reperfusion Injury. Mol Neurobiol. 2015;53(2):932-43

6.Qiu S, Chen T, Koga K, Guo YY, Xu H, Song Q, Wang JJ, Descalzi G, Kaang BK, Luo JH, Zhuo M, Zhao MG*(CA). An Increase in Synaptic NMDA Receptors in the Insular Cortex Contributes to Neuropathic Pain. Science Signaling. 2013; 6(275), ra34

7.Tian Z, Wang Y, Zhang N, Guo YY, Feng B, Liu SB, Zhao MG*(CA). Estrogen receptor GPR30 exerts anxiolytic effects by maintaining the balance between GABAergic and glutamatergic transmission in the basolateral amygdala of ovariectomized mice after stress. Psychoneuroendocrinology. 2013; 38(10): 2218-33

8.Feng B, Liu JC, Zhang J, Ozaki KI, Guo YY, Yi DH, Li XQ, Zhao MG*(CA). Anxiolytic actions of motilin in the basolateral amygdala. Mol Neurobiol. 2013;47(3):892-902

9.Yang Q, Feng B, Zhang K, Guo YY, Liu SB, Wu YM, Li XQ, Zhao MG*(CA). Excessive astrocyte-derived neutrophin-3 contributes to the abnormal neuronal dendritic development in a mouse model of Fragile X Syndrome. PLoS Genetics. 2012;8(12):e1003172

10.Ma L, Wu YM, Guo YY, Yang Q, Feng B, Song Q, Liu SB, Zhao DQ, Zhao MG*(CA). Nicotine Addiction Reduces the Large-Conductance Ca(2+)-activated Potassium Channels Expression in the Nucleus Accumbens. Neuromolecular Med. 2013;15(2):227-37

11.Shi TY, Zhao DQ, Wang HB, Feng S, Liu SB, Xing JH, Qu Y, Gao P, Sun XL, Zhao MG*(CA). A New Chiral Pyrrolyl α-Nitronyl Nitroxide Radical Attenuates β-Amyloid Deposition and Rescues Memory Deficits in a Mouse Model of Alzheimer Disease. Neurotherapeutics. 2013;10(2):340-53

12.Xu ZH, Yang Q, Feng B, Liu SB, Zhang N, Xing JH, Li XQ, Wu YM, Gao GD, Zhao MG*(CA). Group I mGluR antagonist rescues the deficit of D1- induced LTP in a mouse model of fragile X syndrome. Mol Neurodegener. 2012;7(1):24

13.Liu SB, Zhang N, Guo YY, Zhao R, Shi TY, Feng SF, Wang SQ, Yang Q, Li XQ, Wu YM, Ma L, Hou Y, Xiong LZ, Zhang W, Zhao MG*(CA). G-protein coupled receptor 30 mediates rapid neuroprotective effects of estrogen via depression of NR2B-containing NMDA receptors. J Neurosci. 2012,32(14): 4887-4900

14.Guo YY, Liu SB, Cui GB, Ma L, Feng B, Xing JH, Yang Q, Li XQ, Wu YM, Xiong LZ, Zhang W, Zhao MG*(CA). Acute stress induces down-regulation of large-conductance Ca2+-activated potassium channels in the lateral amygdala. J Physiol. 2012;590(Pt 4):875-86

15.Wang HS, Wu LJ, Kim SS, Lee FJ, Gong G, Toyoda H, Ren M, Shang YZ, Xu H, Liu F, Zhao MG*, Zhuo M*. FMRP acts as a key messenger for dopamine modulation in the forebrain. Neuron. 2008;59(4):634-47

16.Toyoda H*, Wu LJ*, Zhao MG *, Xu H, Jia Z, Zhuo M. Long-term depression requires postsynaptic AMPA GluR2 receptor in adult mouse cingulate cortex. J Cell Physiol. 2007; 211(2):336-43

17.Zhao MG, Ko SW, Wu LJ, Toyoda H, Xu H, Quan J, Li J, Jia J, Ren M, Xu ZC, Zhuo M. Enhanced presynaptic neurotransmitter release in the anterior cingulate cortex of the mice with chronic pain. J Neurosci 2006; 26(35):8923-8930

18.Zhao MG, Toyoda H, Lee YS, Wu LJ, Ko S, Zhang XH, Jia YH, Shum F, Xu H, Li BM, Kaang BK, Zhuo M. Roles of NMDA NR2B subtype receptor in prefrontal long-term potentiation and contextual fear memory. Neuron. 2005; 47(6): 859-872

19.Zhao MG, Toyoda H, Ko SW, Ding HK, Wu LJ, Zhuo M. Deficits in trace fear memory and long-term potentiation in a mouse model for fragile X syndrome. J Neurosci. 2005; 25(32): 7385-92

20.Ko S*, Zhao MG*, Toyoda H*, Qiu CS, Zhuo M. Altered behavioral responses to noxious stimuli and fear in glur5- or glur6- deficient mice. J Neurosci. 2005; 25(4): 977-84

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