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滕增辉
2015-07-08 11:25     (点击: )

滕增辉,第四军医大学药学系药剂学教研室副教授,药剂学和药学专业硕士生导师。分别于2001年、2004年、2007年在第四军医大学获临床医学学士、药理学硕士、药理学博士学位,2009年至2011年期间,赴德国明斯特大学医学院做博士后工作。作为课题负责人承担国家自然科学基金课题1项;以主要完成人参与国家自然科学基金11项,国家创新药物重大专项基金3项,陕西省基金4项。已发表科研论文40余篇,其中国外SCI收录23篇,EI收录1篇。获得国家发明专利授权3项。先后主讲药理学、生物药剂学与药代动力学等课程,发表教学论文4篇,主编教材3部。曾多次获嘉奖并荣立个人“三等功”1次。一直从事药物设计、药理学与药物动力学研究工作,研究方向主要包括以下几个方面:

(1)药物代谢动力学:天然多酚类化合物肠道吸收、代谢、转运机制的研究。

(2)神经药理学:精神类疾病分子机制的研究。

(3)靶向递药系统:中枢脑靶向抗精神类疾病药物的研究。

联系方式:tyj2007@fmmu.edu.cn

近年发表的主要论文

(1)Teng Z,Zhang M, Zhao M, Zhang W. Glucocorticoid exerts its non-genomic effect oninhibitory synaptic transmission by activation of a PLC-dependent pathway inPFC of rats.J Physiol. 591(13):3341–3353.(2013)

(2)Teng Z,Yuan C, Zhang F, Huan M, Cao W, Li K, Yang J, Cao D, Zhou S, Mei Q. IntestinalAbsorption and First-pass Metabolism of Polyphenol Compounds in Rat and theirTransport Dynamics in Caco-2 Cells.PLOS ONE. 7:e29647.(2012)

(3)Ye W,*Teng Z,*Liu D, CuiH, Liu M, Cheng Y, Yang T, Mei Q, Zhou S. Synthesis of a new pH-sensitivefolate-doxorubicin conjugate and its antitumor activity in vitro.J PharmSci. 102(2):530-540.(2012)(*co-first author)

(4)Liu R,*Teng Z,*Yuan C,Huan M, Liu X, Zhou S. Liquid Chromatography / Positive-ion Electrospray TandemMass Spectrometry Assay for Nisoldipine in Human Plasma and its Application toa Pharmacokinetic Study.Journal of Liquid Chromatography & RelatedTechnologies. 34: 1800-1810.(2011)(*co-first author)

(5)Liu X,*Teng Z,*Zhang Y, Huan M,Zhou S. High Performance Liquid Chromatography- Tandem Mass Spectrometric Determinationof Resveratrol and Its Metabolites in Rat Tissues.Anal Lett. 43: 557–569.(2010)(*co-first author)

(6)Teng ZH,Zhou SY, Yang RT, Liu XY, Liu RW, Yang X, Zhang BL, Yang JY, CaoDY, Mei QB. Quantitation assay for absorption and first-pass metabolism ofemodin in isolated rat small intestine using liquid chromatography-tandem massspectrometry.Biol Pharm Bull. 30(9):1628-1633.(2007)

(7)Teng ZH,Zhou SY, Ran YH, Liu XY, Yang RT, Yang X, Yuan CJ, Mei QB. Cellularabsorption of anthraquinones emodin and chrysophanol in human intestinal Caco-2cells.Biosci Biotechnol Biochem. 71(7):1636-1643.(2007)

(8)Huan M, Zhang B,Teng Z,Cui H,Wang J, Liu X, Xia H, Zhou S, Mei Q. In Vitro and In Vivo Antitumor Activity ofa Novel pH-Activated Polymeric Drug Delivery System for Doxorubicin.PLoSOne. 7(9):e44116.(2012)

(9)Huan M, Cui H,Teng Z,Zhang B,Wang J, Liu X, Xia H, Zhou S, Mei Q. In vivo anti-tumor activity of a newdoxorubicin conjugate via α-linolenic acid.Biosci Biotechnol Biochem.76(8):1577-9.(2012)

(10)Yang JY, Li X, Gao L,Teng ZH,LiuWC. Co-transfection of dendritic cells with AFP and IL-2 genes enhances theinduction of tumor antigen-specific antitumor immunity.Exp Ther Med.4(4):655-660.(2012)

(11)Wang XJ, Cui H, Wang R, Huan ML, Zhang BL, ZhangWD,Teng ZH,Gan HQ, Zhou SY, Gu Y. Metabolism andPharmacokinetic Study of Ardipusilloside I in Rats.Planta Med.78(6):565-74.(2012)

(12)Cao W, Yang X, Zhou J,Teng Z,CaoL, Zhang X, Fei Z. Targeting 14-3-3 protein, difopein induces apoptosis ofhuman glioma cells and suppresses tumor growth in mice.Apoptosis.15(2):230-241.(2010)

(13)Yuan P, Huang Y, Wu H,Teng Z,Zhang J, Xin X. Induction of a local pseudo-pregnancy via levonorgestrel-loadedmicrospheres for the treatment of endometriosis in a rabbit model.HumReprod. 25(2):462-469.(2010)

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