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李明凯
2015-07-20 17:28     (点击: )

李明凯,1976年2月生,第四军医大学药学系药理学教研室副教授,硕士研究生导师,副主任工作。1999年毕业于第四军医大学临床医学专业,2002年和2005年分别获第四军医大学药理学专业硕士学位和博士学位。2006-2010年在美国马里兰大学医学院从事博士后研究。现担任陕西省生理科学会理事,Molecular Medicine ReportsActa Pharmacologica Sinica等国际专业杂志审稿专家。

主要从事抗耐药菌小分子药物和心血管药理研究工作。承担或参与国家自然科学基金、国家新药创制基金、军队后勤面上项目、陕西省科技统筹创新工程计划项目等多项课题;以第一作者或通讯作者发表SCI论文20余篇,主编专著2部,参编国内外专著7部,国家级规划教材2部;第一申请人获批国家发明专利1项;先后获得“AUA/Gyrus ACMI Prize Essay Contest LaboratoryResearch”国际论文竞赛第二名,“Annual Jack Lapides Essay Contest inNeurourology”国际论文竞赛优秀奖等5个国际奖项,获陕西省科学技术一等奖1项(排名第三);陕西省自然科学优秀学术论文二等奖2项(排名第一)。

代表性论著

[1]Li Z, Li J, Qu D, Hou Z, Yang X, ZhangZ, Wang Y, Luo X,Li M*.Synthesisand pharmacological evaluations of 4-hydroxycoumarin derivatives as a new classof anti-Staphylococcus aureus agents.J Pharm Pharmacol. 2015,67(4):573-82.

[2]XueX, Mao X, Li Z, Chen Z, Zhou Y, Hou Z,Li M, Meng J, Luo X. Apotent and selective antimicrobial Poly(amidoamine) dendrimer conjugate withLED209 targeting QseC receptor to inhibit the virulence genes of Gram negativebacteria.Nanomedicine. 2015, 11(3):329-339.

[3]Meng J, Da F, Ma X, Wang N, Wang Y, Zhang H,LiM, Zhou Y, Xue X, Hou Z, Jia M, Luo X. Antisense Growth Inhibition ofMethicillin-Resistant Staphylococcus aureus by Locked Nucleic Acid Conjugatedwith Cell-Penetrating Peptide as a Novel FtsZ Inhibitor.AntimicrobAgents Chemother, 2015, 59(2):914-922.

[4]QuD ,Li J, Yang X, Zhang Z, Luo X,Li M*, Li X*. New biscoumarinderivatives: synthesis, crystal structure, theoretical study and antibacterialactivity against Staphylococcus aureus.Molecules.2014, 19(12):19868-79.

[5]Li J, Hou Z, Chen G, Li F, Zhou Y, XueX, Li Z, Jia M, Zhang Z,Li M*, Luo X *.Synthesis, antibacterialactivities, and theoretical studies of dicoumarols.Org Biomol Chem.2014;12(29):5528-5535.

[6]Li J, Hou Z, Li F, Zhng Z, Zhou Y, LuoX,Li M*. Synthesis, photoluminescent, antibacterial activitiesand theoretical studies of 4-hydroxycoumarin derivatives.J Mol Sruct.2014;1075:509-514.

[7]LiM, Li J, Li F, Liu B, Zhou Y, Li X, XueX, Hou Z, LuoX. Synthesis, crystal structures, and anti-drug-resistantStaphylococcus aureus activities of novel 4-hydroxycoumarin derivatives.EurJ Pharmacol. 2013,721(1-3):151-157.

[8]LiM, Li J, Liu B, Zhou Y, Xue X, ShiX, Tu Z, Hou Z, LuoX. Synthesis, photoluminescent behaviors, and antibacterialactivities of 3-acetylcoumarins.Research on chemical intermediates.2013, DOI 10.1007/s11164-013-1432-5.

[9]LiM, Sun Y, Tomiya N, Hsu Y, Chai TC.Elevated polyamines in urothelial cells from OAB subjects mediateoxotremorine-evoked rapid intracellular calcium rise and delayed acetylcholinerelease.Am J Physiol Renal Physiol.2013; 305(4): F445-50.

[10]LiM, Luo X. Histamine in the peripheralnervous system: a modulator or neurotransmitter. Advances in medicine andbiology.Nova Science Publishers. 2012,P73-94.

[11]LiM, Sun Y, Simard JM, Chai TC. Increasedtransient receptor potential vanilloid type 1 (TRPV1) signaling in idiopathicoveractive bladder urothelial cells.Neurourol Urodyn.2011;30:606-611.

[12]LiM, Sun Y, Simard JM, Wang JY, Chai TC.Augmented bladder urothelial polyamine signaling and block of BK-channel in thepathophysiology of overactive bladder syndrome.Am J Physiol Cell Physiol.2009; 297: C1445-C1451.

[13]LiM, Hu J, Chen T, Meng J, Ma X, Li J, JiaM, Luo X. Histamine in Macaca mulatto monkeycardiac sympathetic nerve system: A morphological and functional assessment.AutonNeurosci.2007; 137: 37-43.

[14]LiM, Hu J, Chen Z, Meng J, Wang H, MaX, Luo X. Evidence for histamine as a neurotransmitter in the cardiacsympathetic nerve system.Am J Physiol Heart andCirc Physiol. 2006; 291:H45-51.

[15]Li M,Luo X, Chen L. Co-localization of histamine and dopamine-b-hydroxylasein sympathetic ganglion and release of histamine from cardiac sympatheticterminals of guinea pig.Auto Auta Pharmacol. 2004; 23: 327-333.

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