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李明凯
2017-12-25 17:28     (点击: )

李明凯  第四军医大学药学系药理学教研室副教授,硕士研究生导师,第四军医大学精准用药与创新药物研究中心副主任。1999年毕业于第四军医大学临床医学专业,2002年和2005年分别获第四军医大学药理学专业硕士学位和博士学位。2006-2010年在美国马里兰大学医学院从事博士后研究。现为中国药理学会化疗药理学专业委员会青年委员,陕西省药理学会常务理事,Microbial Pathogenesis等多个国际专业杂志审稿专家。主要从事抗感染药理和心血管药理学研究工作,先后负责国家自然科学基金项目、军队后勤科研面上项目、陕西省科技攻关项目等6项课题;以第一作者或通讯作者发表SCI论文24篇,主编专著1部,参编国内外专著8部,国家级规划教材5部;获批国家发明专利3项;获得国际论文竞赛第二名等5个国际奖项,荣获陕西省科学技术一等奖1项(排名第三);陕西省自然科学优秀学术论文二等奖2项(排名第一)。

代表性论著

[1] Chen M, Xin J, Liu B, Luo L, Li J, Yin W, Li M*. Mitogen-Activated Protein Kinase and Intracellular Polyamine Signaling Is Involved in TRPV1 Activation-Induced Cardiac Hypertrophy. J Am Heart Assoc. 2016;5(8). pii: e003718.  

[2] Li J, Xue X, Li X, Hou Z, Yang X, Qu D, Zhou Y, Zhang Z, Luo X, Li J, Li M*.Synthesis of biscoumarin and dihydropyran derivatives as two novel classes of potential anti-bacterial derivatives. Arch Pharm Res. 2016; 39(10):1349-1355.

[3] Hou Z, Zhou Y, Li J, Zhang X, Shi X, Xue X, Li Z, Ma B, Wang Y, Li M*, Luo X*. Selective in vivo and in vitro activities of 3,3'-4-nitrobenzylidene-bis-4- hydroxycoumarin against methicillin-resistant Staphylococcus aureus by inhibition of DNA polymerase III. Sci Rep. 2015;5:13637.

[4] Li J, Lv C, Li X, Qu D, Hou Z, Jia M, Luo X, Li X, Li M*. Synthesis of Biscoumarin and Dihydropyran Derivatives and Evaluation of Their Antibacterial Activity. Molecules. 2015,20(9):17469-82.

[5] Sui Y, Huo H, Xin J, Li J, Li X, Du X, Ma H, Zhou H, Zhan H, Wang Z, Li C, Sui F, Li M*.Antibacterial and Antitumor Activities of Biscoumarin and Dihydropyran Derivatives. Molecules. 2015, 20(9):17614-26.

[6] Li Z, Li J, Qu D, Hou Z, Yang X, Zhang Z, Wang Y, Luo X, Li M*.Synthesis and pharmacological evaluations of 4-hydroxycoumarin derivatives as a new class of anti-Staphylococcus aureus agents. J Pharm Pharmacol. 2015, 67(4):573-82.

[7] Qu D ,Li J, Yang X, Zhang Z, Luo X, Li M*, Li X*. New biscoumarin derivatives: synthesis, crystal structure, theoretical study and antibacterial activity against Staphylococcus aureus. Molecules.2014, 19(12): 19868-79.

[8] Li J, Hou Z, Chen G, Li F, Zhou Y, Xue X, Li Z, Jia M, Zhang Z, Li M*, Luo X *.Synthesis, antibacterial activities, and theoretical studies of dicoumarols. Org Biomol Chem. 2014;12(29):5528-5535.

[9] Li J, Hou Z, Li F, Zhng Z, Zhou Y, Luo X, Li M*. Synthesis, photoluminescent, antibacterial activities and theoretical studies of 4-hydroxycoumarin derivatives. J Mol Sruct. 2014;1075:509-514.

[10]Li M, Li J, Li F, Liu B, Zhou Y, Li X, Xue X, Hou Z, LuoX. Synthesis, crystal structures, and anti-drug-resistant Staphylococcus aureus activities of novel 4-hydroxycoumarin derivatives. Eur J Pharmacol. 2013,721(1-3):151-157.

[11]Li M, Sun Y, Tomiya N, Hsu Y, Chai TC. Elevated polyamines in urothelial cells from OAB subjects mediate oxotremorine-evoked rapid intracellular calcium rise and delayed acetylcholine release. Am J Physiol Renal Physiol. 2013; 305(4): F445-50.

[12]Li M, Sun Y, Simard JM, Chai TC.  Increased transient receptor potential vanilloid type 1 (TRPV1) signaling in idiopathic overactive bladder urothelial cells. Neurourol Urodyn. 2011;30:606-611.

[13]Li M, Sun Y, Simard JM, Wang JY, Chai TC. Augmented bladder urothelial polyamine signaling and block of BK-channel in the pathophysiology of overactive bladder syndrome. Am J Physiol Cell Physiol. 2009; 297: C1445-C1451.

[14]Li M, Hu J, Chen T, Meng J, Ma X, Li J, Jia M, Luo X.  Histamine in Macaca mulatto monkey cardiac sympathetic nerve system: A morphological and functional assessment. Auton Neurosci. 2007; 137: 37-43.

[15]Li M,  Hu J, Chen Z, Meng J, Wang H, Ma X, Luo X. Evidence for histamine as a neurotransmitter in the cardiac sympathetic nerve system. Am J Physiol Heart and Circ Physiol. 2006; 291:H45-51.

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